Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr??ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF219 (Zinc finger protein 219) is a 722 amino acid protein belonging to the Kr??ppel C2H2-type zinc-finger protein family. It is ubiquitously expressed and localizes to the nucleus. Containing 6 C2H2-type zinc fingers which function to bind DNA, ZNF219 is thought to be involved in transcriptional regulation. Specifically, ZNF219 has been identified as a transcriptional repressor that downregulates the transcription of the HMG-14 promoter.

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