HHAT抗体
交货期:1周
产品别名:Anti-HHAT
Anti-hedgehog acyltransferase Antibody
靶标:
HHAT
产品别名:
MART2; NNMS; SKI1; Skn; HHAT; hedgehog acyltransferase; hedgehog acyltransferase; protein-cysteine N-palmitoyltransferase HHAT; melanoma antigen recognized by T-cells 2; skinny hedgehog protein 1;
背景信息:
HHAT is a 493 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and belongs to the membrane-bound acyltransferase family. Expressed ubiquitously, HHAT functions to catalyze the N-terminal palmitoylation of SSH (slingshot homolog), an event that is required for SHH signaling pathways. HHAT is expressed in cancer cell lines, suggesting a role for HHAT in tumorigenesis. The gene encoding HHAT maps to human chromosome 1 and is expressed as four alternatively spliced isoforms. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. Several disorders, including Stickler syndrome, Parkinsons Disease, Gaucher disease, malignant melanoma and Usher syndrome, are caused by defects in genes that localize to chromosome 1.
产品发布日期:2026.03.23