Netrin G1 and Netrin G2, also referred to as laminet-1 and laminet-2, are membrane bound axon guidance molecules involved in synaptic formation and maintenance. They comprise a subgroup within the UNC-6/netrin family. Both genes have been associated with schizophrenia involving single nucleotide polymorphisms. They are both expressed in the brain but G1 is most predominantly expressed in the thalamus and G2 is most predominantly expressed in the cortex and hippocampus. These two proteins differ from classical netrins by their failure to bind netrin receptors, the presence of a glycosyl phosphatidylinositol membrane anchor, and the generation of multiple isoforms. Netrin G2 contains one laminin N-terminal domain and three laminin EGF-like domains. It selectively interacts with LRRC4 and this association may mediate cell adhesion. In addition, Netrin G2 is significantly downregulated in bladder transitional cell carcinoma (TCC) and may be a putative tumor suppressor gene.

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