锌指蛋白828抗体
交货期：1周
产品别名：Anti-Champ1
Anti-chromosome alignment maintaining phosphoprotein 1 Antibody
Anti-chromosome alignment maintaining phosphoprotein 1 Antibody
靶标：
产品别名：
背景信息：
Champ1
产品别名：
AA675043； AI116001； D8Ertd457e； D8Ertd569e； Zfp828； Znf828； mKIAA1802； Champ1； chromosome alignment maintaining phosphoprotein 1； chromosome alignment maintaining phosphoprotein 1； chromosome alignment-maintaining phosphoprotein 1； zinc finger protein 828； 锌指蛋白828；
背景信息：
CHAMP1 (chromosome alignment maintaining phosphoprotein 1), also known as ZNF828 or C13orf8, is a 812 amino acid protein containing one C2H2-type zinc finger. CHAMP1 is required for the proper alignment of chromosomes during metaphase, undergoing CDK1-dependent phosphorylation at multiple sites during mitosis. The phosphorylation counteracts the negative chromosomal alignment regulation of the zinc-finger domain of CHAMP1. One region of CHAMP1, the FPE region, is responsible for spindle and kinetochore localization, which is essential for proper chromosome alignment. CHAMP1 interacts with MAD2L2, PGOZ, CBX1, CBX3 and CBX5, and may recruit CENPE and CENPF to the kinetochore. The CHAMP1 gene is located on chromosome 13 and is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat and chicken.
产品发布日期：2026.01.26
广州伟伯科技有限公司