钾离子通道多聚体结构域蛋白21抗体
交货期：1周
产品别名：Anti-KCTD21
Anti-potassium channel tetramerization domain containing 21 Antibody
Anti-potassium channel tetramerization domain containing 21 Antibody
靶标：
产品别名：
背景信息：
KCTD21
产品别名：
KCASH2； KCTD21； potassium channel tetramerization domain containing 21； potassium channel tetramerization domain containing 21； BTB/POZ domain-containing protein KCTD21； potassium channel tetramerisation domain containing 21； potassium channel tetramerization domain-containing protein 21； 钾离子通道多聚体结构域蛋白21；
背景信息：
Swiss-Prot Acc.Q4G0X4.Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
产品发布日期：2026.03.31
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