重组ETV3蛋白
交货期：1周
产品别名：Recombinant ETV3
Recombinant ETS variant transcription factor 3 protein
Recombinant ETS variant transcription factor 3 protein
基因名：
产品别名：
背景信息：
ETV3
产品别名：
METS； PE-1； PE1； ETV3； ETS variant transcription factor 3； ETS variant transcription factor 3； ETS translocation variant 3； ETS domain transcriptional repressor PE1； ets variant gene 3, ETS family transcriptional repressor； mitogenic Ets transcriptional suppressor； ETV3蛋白；
背景信息：
ETV3 belongs to the ETS family of transcription factors and functions as a transcriptional repressor. ETS family members share a highly conserved DNA binding domain and play a role in growth factor pathways regulating proliferation and differentiation. PE-1 is ubiquitously expressed and localizes to the nucleus. Its expression can be induced by IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10 downstream anti-inflammatory effects. During terminal cell differentiation, PE-1 plays a role in growth arrest by specifically repressing the target genes that are involved in Ras-dependent proliferation. The contributions of PE-1 to these anti-proliferative effects are heavily dependent on its interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing events.
产品发布日期：2026.01.24
广州伟伯科技有限公司