重组蛋白转运抑制剂GBF1
交货期：1周
产品别名：Recombinant GBF1
Recombinant golgi brefeldin A resistant guanine nucleotide exchange factor 1 protein
Recombinant golgi brefeldin A resistant guanine nucleotide exchange factor 1 protein
基因名：
产品别名：
背景信息：
GBF1
产品别名：
ARF1GEF； CMT2GG； GBF1； golgi brefeldin A resistant guanine nucleotide exchange factor 1； golgi brefeldin A resistant guanine nucleotide exchange factor 1； Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1； BFA-resistant GEF 1； 蛋白转运抑制剂GBF1；
背景信息：
Protein trafficking to the membrane requires formation of coated carrier vesicles, such as COPI-coated vesicles from the cis-golgi, a process triggered by membrane binding of the GTP-bound form of ADP-ribosylation factors. Normally, brefeldin A (BFA) blocks this action by inhibiting guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factor. However, GBF1, a member of the sec7-domain family of GEFs, allows cells to maintain normal golgi morphology and grow in the presence of BFA. The gene encoding the human GBF1 protein maps to chromosome 10q24, with the sec7-domain centrally positioned, and a proline-rich C-terminus. Based on mutatagenesis analysis, this proline rich region appears to interact with p115 in a functionally significant manner.
产品发布日期：2026.03.20
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