重组半胱氨酸蛋白酶8相关蛋白2
交货期：1周
产品别名：重组胱天蛋白酶8关联蛋白2(CASP8AP2)
Recombinant CASP8AP2
Recombinant CASP8AP2
基因名：
产品别名：
背景信息：
CASP8AP2
产品别名：
CED-4； FLASH； RIP25； CASP8AP2； caspase 8 associated protein 2； caspase 8 associated protein 2； CASP8-associated protein 2； FLASH homolog RIP25； FLICE associated huge； FLICE-associated huge protein； human FLASH； 半胱氨酸蛋白酶8相关蛋白2； 胱天蛋白酶8关联蛋白2(CASP8AP2)；
背景信息：
FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.
Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.
Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.
产品发布日期：2026.01.26
广州伟伯科技有限公司