重组Nebulette蛋白(NEBL)
交货期：1周
产品别名：重组肌动蛋白结合蛋白Z盘状蛋白
Recombinant NEBL
Recombinant NEBL
基因名：
产品别名：
背景信息：
NEBL
产品别名：
C10orf113； LASP2； LNEBL； bA165O3.1； NEBL； nebulette； nebulette； nebulette； LIM and SH3 protein 2； LIM-nebulette； actin-binding Z-disk protein； Nebulette蛋白(NEBL)； 肌动蛋白结合蛋白Z盘状蛋白；
背景信息：
Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy.
Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.
Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.
产品发布日期：2026.03.20
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