重组SH2B蛋白
交货期：1周
产品别名：Recombinant Sh2b1
Recombinant SH2B adaptor protein 1 protein
Recombinant SH2B adaptor protein 1 protein
基因名：
产品别名：
背景信息：
Sh2b1
产品别名：
AI425885； C530001K22Rik； Irip； Psm； SH2-B； SH2-Bb； Sh2bpsm1； mKIAA1299； Sh2b1； SH2B adaptor protein 1； SH2B adaptor protein 1； SH2B adapter protein 1； SH2 domain-containing protein 1B； SH2-B PH domain containing signaling mediator 1； pro-rich, PH and SH2 domain-containing signaling mediator； SH2B蛋白；
背景信息：
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1.
产品发布日期：2026.03.20
广州伟伯科技有限公司