ZFP30 is a 519 amino acid protein that localizes to the nucleus and is composed of thirteen C2H2-type zinc fingers and one KRAB domain. ZFP30 is encoded by a gene located on human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fc receptors (FcRs).

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