重组SCK蛋白
交货期：1周
产品别名：重组SHC-转化蛋白2(SHC2)
Recombinant SHC2
Recombinant SHC2
基因名：
产品别名：
背景信息：
SHC2
产品别名：
SCK； SHCB； SLI； SHC2； SHC adaptor protein 2； SHC adaptor protein 2； SHC-transforming protein 2； SH2 domain protein C2； SHC (Src homology 2 domain containing) transforming protein 2； SHC-transforming protein B； neuronal Shc adaptor homolog； protein Sck； src homology 2 domain-containing-transforming protein C2； SCK蛋白； SHC-转化蛋白2(SHC2)；
背景信息：
Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).
产品发布日期：2026.03.18
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