重组信号诱导增殖相关蛋白1样蛋白1
交货期：1周
产品别名：Recombinant SIPA1L1
Recombinant signal induced proliferation associated 1 like 1 protein
Recombinant signal induced proliferation associated 1 like 1 protein
基因名：
产品别名：
背景信息：
SIPA1L1
产品别名：
E6TP1； SPAR1； SIPA1L1； signal induced proliferation associated 1 like 1； signal induced proliferation associated 1 like 1； signal-induced proliferation-associated 1-like protein 1； SIPA1-like protein 1； high-risk human papilloma viruses E6 oncoproteins targeted protein 1； spine-associated RapGAP 1； 信号诱导增殖相关蛋白1样蛋白1；
背景信息：
SIPA1L1 (Signal-induced proliferation associated-like protein 1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
产品发布日期：2025.08.07
广州伟伯科技有限公司