重组鞘磷脂沉积病C1样蛋白1
交货期：1周
产品别名：Recombinant NPC1L1
Recombinant NPC1 like intracellular cholesterol transporter 1 protein
Recombinant NPC1 like intracellular cholesterol transporter 1 protein
基因名：
产品别名：
背景信息：
NPC1L1
产品别名：
LDLCQ7； NPC11L1； SLC65A2； NPC1L1； NPC1 like intracellular cholesterol transporter 1； NPC1 like intracellular cholesterol transporter 1； NPC1-like intracellular cholesterol transporter 1； NPC1 (Niemann-Pick disease, type C1, gene)-like 1； NPC1 like 1； niemann-Pick C1-like protein 1； 鞘磷脂沉积病C1样蛋白1；
背景信息：
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
产品发布日期：2026.01.26
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