重组HJURP蛋白
交货期：1周
产品别名：Recombinant HJURP
Recombinant Holliday junction recognition protein
Recombinant Holliday junction recognition protein
基因名：
产品别名：
背景信息：
HJURP
产品别名：
FAKTS； URLC9； hFLEG1； HJURP； Holliday junction recognition protein； Holliday junction recognition protein； Holliday junction recognition protein； 14-3-3-associated AKT substrate； fetal liver expressing gene 1； fetal liver-expressing gene 1 protein； up-regulated in lung cancer 9； HJURP蛋白；
背景信息：
HJURP is a 748 amino acid protein that is expressed in thymus, placenta, small intestine, liver, skeletal muscle, bone marrow and colon. When histone H3-like variant CENP-A nucleosomes are assembled, HJURP localizes in centromeres during late telophase and early G1 phase, and localizes to the nucleolus during S phase. Considered a centromeric protein, HJURP plays a central role in the incorporation and maintenance of CENP-A at centromeres. HJURP also acts as a specific chaperone for CENP-A and is required for the incorporation of newly synthesized CENP-A molecules into nucleosomes at replicated centromeres. HJURP is considered an indispensable factor for chromosomal stability in immortalized cancer cells and is a potential novel therapeutic target for the development of anticancer drugs.
产品发布日期：2026.01.26
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