重组上皮钙粘附分子结合蛋白E7
交货期：1周
产品别名：Recombinant CBLL1
Recombinant Cbl proto-oncogene like 1 protein
Recombinant Cbl proto-oncogene like 1 protein
基因名：
产品别名：
背景信息：
CBLL1
产品别名：
HAKAI； RNF188； CBLL1； Cbl proto-oncogene like 1； Cbl proto-oncogene like 1； E3 ubiquitin-protein ligase Hakai； Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1； Cbl proto-oncogene like 1, E3 ubiquitin protein ligase； Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1； E-cadherin binding protein E7； RING finger protein 188； RING-type E3 ubiquitin transferase Hakai； c-Cbl-like protein 1； casitas B-lineage lymphoma-transforming sequence-like protein 1； 上皮钙粘附分子结合蛋白E7；
背景信息：
CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
产品发布日期：2026.03.18
广州伟伯科技有限公司