精神障碍相关GAP蛋白抗体
交货期：1周
产品别名：Anti-SRGAP3
Anti-SLIT-ROBO Rho GTPase activating protein 3 Antibody
Anti-SLIT-ROBO Rho GTPase activating protein 3 Antibody
靶标：
产品别名：
背景信息：
SRGAP3
产品别名：
ARHGAP14； MEGAP； SRGAP2； WRP； SRGAP3； SLIT-ROBO Rho GTPase activating protein 3； SLIT-ROBO Rho GTPase activating protein 3； SLIT-ROBO Rho GTPase-activating protein 3； SLIT-ROBO Rho GTPase activating protein 2； WAVE-associated Rac GTPase activating protein； mental disorder-associated GAP； rho GTPase-activating protein 14； 精神障碍相关GAP蛋白；
背景信息：
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
产品发布日期：2026.05.11
广州伟伯科技有限公司