重组Rho GTP酶激活蛋白15
交货期：1周
产品别名：Recombinant ARHGAP15
Recombinant Rho GTPase activating protein 15 protein
Recombinant Rho GTPase activating protein 15 protein
基因名：
产品别名：
背景信息：
ARHGAP15
产品别名：
BM046； ARHGAP15； Rho GTPase activating protein 15； Rho GTPase activating protein 15； rho GTPase-activating protein 15； rho-type GTPase-activating protein 15； Rho GTP酶激活蛋白15；
背景信息：
Rho GTPases, which play fundamental roles in numerous cellular processes, are initiated by external stimuli that signal though G-protein coupled receptors. ARHGEF15 (Rho guanine nucleotide exchange factor (GEF) 15), also known as ARGEF15 or Vsm-RhoGEF, is a 841 amino acid protein expressed in the vascular smooth muscle of coronary artery. ARHGEF15 functions as a specific guanine nucleotide exchange factor for RhoA and interacts with ephrin-A4 in vascular smooth muscle cells. Containing one DH (DBL-homology) domain, ARHGEF15 is phosphorylated on tyrosine residues upon ephrin-A1 stimulation. The DH domain consists of a region of about 150 amino acids that induces Rho family GTPases to release GDP. This effectively activates the Rho GTPase by allowing GTP binding. ARHGEF15 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
产品发布日期：2026.05.09
广州伟伯科技有限公司